ABSTRACT
Background: The present study was carried out to evaluate the antipyretic activity of alcoholic extract of Murraya koenigii leaves in rabbits by using PGE1 induced hyperpyrexia method. We found that not much work has been done on the antipyretic effect of this plant.Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 1000-1500 gm were used in the study. The animals were divided into five groups (n=6). The rabbits of all the groups were made febrile by injecting misoprostol (PGE1) subcutaneously in the dose of 100 mcg/kg. For group 1 and 2, normal saline 2ml/kg as control and aspirin 28mg/kg as standard were given respectively. Alcoholic extract of Murraya koenigii leaves in the doses of 200, 400 and 800mg/kg were administered in remaining three groups respectively. Rectal temperatures were recorded with help of digital thermometer for every 30 min after drug treatment.Results: Alcoholic extract of Murraya koenigii produced highly significant (p<0.001) antipyretic effect in 400 and 800 mg/kg doses. But onset of action was fast with 800mg/kg dose.Conclusions: This study concludes that Alcoholic extract of Murraya koenigii has fast onset of action and also exhibited sustained anti pyretic action in New Zealand rabbits.
ABSTRACT
Dyskinesia hyperpyrexia syndrome is a rare medical emergency in Parkinson's disease. It is characterized by continuous dyskinesia associated with hyperthermia, rhabdomyolysis, and alteration of the mental state. We present the case of a 74-year-old woman who presented with recurrent dyskinesia hyperpyrexia syndrome. Although some provocation factors and clinical manifestations seem to be shared with parkinsonism hyperpyrexia syndrome, a clear distinction in management should be considered.
Subject(s)
Aged , Female , Humans , Dyskinesias , Emergencies , Fever , Parkinson Disease , Parkinsonian Disorders , RhabdomyolysisABSTRACT
Se presenta el caso de una paciente con hemorragia posparto (HPP) secundaria a atonía uterina, tratada con misoprostol 1.000μg por vía sublingual, y el curso de su evolución, en la que la hiperpirexia como efecto secundario por la vía de administración elegida, y la presentación clínica, generan dificultad diagnóstica e intervenciones especiales dentro del proceso de manejo. Se realiza una revisión de la literatura acerca del misoprostol, sus perfiles farmacocinéticos y sus efectos secundarios. Se concluye que el misoprostol, administrado por vía sublingual, procura la concentración máxima más alta y se asocia con la incidencia más alta de efectos secundarios en comparación con otras vías.
This is a patient with post-partum hemorrhage (PPH), secondary to uterine atony managed with sub-lingual misoprostol 1000μg . Hyperpyrexia resulting from the route of administration of the drug and the clinical presentation of the condition, give rise to diagnostic difficulties and special interventions during the management process. A literature review on misoprostol, its pharmacological profile and side effects concluded that sub-lingual misoprostol results in a maximum concentration and is associated with the highest incidence of side effects as compared to other routes of administration.
Subject(s)
HumansABSTRACT
Objective To observe curative effect of acupuncture treating children acute upper respiratory infections (AURI).Methods According to random digits table,150 children from clinic emergency department were averagely bring into a acupuncture treatment group and a western medicine treatment group.Patients in the acupuncture treatment group received the treatments of acupunctureing one side of “SiGuan”points,bloodletting in apex satyri,and reducing temperature with tepid sponge bath; while patients in the western medicine treatment group received the treatments of taking ibuprofen suspension,using external pyretolysis patches on forehead,and reducing temperature with an alcohol sponge bath.After the treatment,the near future therapeutic effects:the time of pyretolysis,fevering again in 24 hours and convulsion time,and the prostecdtive efficacy:the time of cough continuing,AURI happening again in 3 months and recovery time of appetite were both observed.Results The time of pyretolysis,fevering again in 24 hours,convulsion time,the time of cough continuing,recovery time of appetite and AURI happening again in 3 months of acupuncture treatment group was(15.6±5.8) minutes,(12.7±3.3) hours,(0.6±0.1) times,(2.3±1.8) days,(2.4±1.6)days,and (35.2±3.9) days respectively; and the western medicine treatment group was (25.5±7.3) minutes,(8.6±4.1) hours,(2.1±0.5) times (6.2±2.4) days,(3.8±1.5) days,and (18.4±5.2) days respectively.Comparing between the two groups,P＜0.05.Conclusion Acupuncture can significantly decrease the time of pyretolysis,cough continuing,recovery time of appetite and convulsion time,and significantly increase the time of fevering again in 24 hours and AURI happening again in 3 months in patients with AURI.
ABSTRACT
A few patients with Parkinson's disease (PD) crave large amounts of levodopa therapy far beyond those needed to alleviate their symptoms, even in the state of overdose complication. Such harmful pattern of compulsive dopaminergic drug use is called as dopamine dysregulation syndrome (DDS). We report a chronic stage PD patient presenting with high fever and altered mentality, who had the DDS as well as the Parkinsonism hyperpyrexia syndrome (PHS).
Subject(s)
Humans , Dopamine , Fever , Levodopa , Parkinson Disease , Parkinsonian DisordersABSTRACT
@#ObjectiveTo observe the effect of mild hypothermia on vital signs of the elderly patients with anterior circulation brain infarction (massive hemispheric infarction) and hyperpyrexia.Methods46 elderly patients with massive hemispheric infarction and hyperpyrexia within the first 24 hours after onset were randomly divided into the control group and the hypothermia group with 23 cases in each group. The patients of the hypothermia group were treated with mild hypothermia therapy (33℃～35℃). Those of the control group were treated with routine hypothermal treatment. The temperature and heart rate of all patients were measured after 10 days; the prognosis was evaluated according to mortality and scores of Neurological Deficit Scale (NDS).ResultsFor patients of the hypothermia group, the temperature and heart rate significantly reduced, death rate was significantly lower, the neurological function distinctly improved and prognosis was better than the control group after 10 days treatment ( P<0.05).Conclusion Mild hypothermia is safe and effective to elderly patients with massive hemispheric infarction and hyperpyrexia.
ABSTRACT
Malignant hyperthermia is a potentially fatal hypermetabolic syndrome characterized by hyperpyr-exia and skeletal muscle rigidity. It can be induced by all of the currently used inhalation anesthetics or by injection of succinylcholine. This case is presented of a 32 year old healthy male patient in whom a orthopedic operation was performed under O2-N2O-enflurane anesthesia with induction by pentothal sodium and succinylcholine. One hour after induction, tachycardia developed and was followed by unstable blood pressure, hyperpyrexia, arrhythmia and muscle rigidity. Anesthesia was terminated and vigorous emergency treatment was attempted. But the patient died about 4 hours after induction of anesthesia. The etiologic factors, clinical feature, treatment and prevention of malignant hyperthermia are discussed.
Subject(s)
Adult , Humans , Male , Anesthesia , Anesthesia, General , Anesthetics, Inhalation , Arrhythmias, Cardiac , Blood Pressure , Emergency Treatment , Malignant Hyperthermia , Muscle Rigidity , Muscle, Skeletal , Orthopedics , Sodium , Succinylcholine , Tachycardia , ThiopentalABSTRACT
Malignant hyperthermia is a potentially fatal hypermetabolic syndrome characterized by hyperpyr-exia and skeletal muscle rigidity. It can be induced by all of the currently used inhalation anesthetics or by injection of succinylcholine. This case is presented of a 32 year old healthy male patient in whom a orthopedic operation was performed under O2-N2O-enflurane anesthesia with induction by pentothal sodium and succinylcholine. One hour after induction, tachycardia developed and was followed by unstable blood pressure, hyperpyrexia, arrhythmia and muscle rigidity. Anesthesia was terminated and vigorous emergency treatment was attempted. But the patient died about 4 hours after induction of anesthesia. The etiologic factors, clinical feature, treatment and prevention of malignant hyperthermia are discussed.